Ex Parte Aleles et al - Page 10



             Appeal No. 2006-2248                                                                               
             Application No. 10/158,618                                                                         

                   [I]t would have been obvious to one of ordinary skill in the art at the                      
                   time the invention was made to prepare [Granger’s example 4] and                             
                   add the specific fatty alcohol ester [octyl hydroxyl stearate] expecting                     
                   beneficial effect, i.e. the compositions [would] exhibit better                              
                   emolliency.                                                                                  
                          29. In due course, Applicants filed an amendment responding to the                    
             Examiner's first Office action.                                                                    
                          30. As shown in Appendix 2 of this opinion, the amendment:                            
                                (1) added new claim 11 and                                                      
                                (2) amended claims 1 and 5,                                                     
                          31. New independent claim 11 covers a very specific embodiment                        
             of the compounds covered by claim 1.  After entry of the amendment, the                            
             application claims were 1-11.                                                                      
                          32.  In the amendment, Applicants stated as follows:                                  
                   Applicant’s invention is directed to retinoid compositions which have a low                  
                   irritation profile.  As amended, Applicant’s invention claims a retinoid                     
                   composition having a pH from about 4 to about 7.   Felty neither teaches or                  
                   suggests a retinoid composition having a pH from about 4 to about 7 or a                     
                   retinoid composition which have a low irritation profile (the bottom of page                 
                   6 and top of page 7).                                                                        
                          33.  In the amendment, Applicants also stated as follows:                             
                   Granger neither teaches nor suggests a retinoid composition having a                         
                   specific pH range (page 7).                                                                  

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