Appeal 2006-1953
Application 10/195,347
24. The device of claim 1, wherein the anchor is formed of naturally
occurring extracellular matrix cured and shaped to fasten into a subchondral
portion of the bone.
42. A cartilage repair device for repairing damaged or diseased articular
cartilage,the device comprising:
a plug;
cells seeded on the plug; and
an anchor configured to support and position the plug in a
position which is proximate to healthy tissue;
wherein at least one of the plug and the anchor comprise
naturally occurring extracellular matrix; and
wherein the cells are selected from the group consisting of:
chondrocytes; fibrochondrocytes; osteocytes; ostoeblasts; osteoclasts;
synoviocytes; bone marrow cells; mesenchymal cells; stromal cells;
stem cells; embryonic stem cells; precursor cells derived from adipose
tissue; peripheral blood progenitor cells; stem cells isolated from adult
tissue; genetically transformed cells; a combination of chondrocytes
and other cells; a combination of osteocytes and other cells; a
combination of synoviocytes and other cells; a combination of bone
marrow cells and other cells; a combination of mesenchymal cells and
other cells; a combination of stromal cells and other cells; a
combination of stem cells and other cells; a combination of embryonic
stem cells and other cells; a combination of precursor cells isolated
from adult tissue and other cells; a combination of peripheral blood
progenitor cells and other cells; a combination of stem cells isolated
from adult tissue and other cells; and a combination of genetically
transformed cells and other cells.
50. The device of claim 42, wherein the plug comprises naturally
occurring extracellular matrix selected from the group consisting of:
lyophilized naturally occurring extracellular matrix material; comminuted
naturally occurring extracellular matrix material; naturally occurring
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