Ex Parte Leiden et al - Page 10


                 Appeal 2006-1971                                                                                    
                 Application 10/144,224                                                                              

            1           22. In one method of the invention of Misner, a mechanical                                   
            2                     pressure is applied in an amount between diastolic and                             
            3                     systolic pressure, thereby enhancing the pulsability of the                        
            4                     arterial wall.  The application of mechanical pressure                             
            5                     substantially enhances the pulse relative to the magnitude of                      
            6                     the normal cardiac pulse. (col. 5, ll. 58-67).                                     
            7           23. Controllable pressure device 10 exerts a pressure on a body                              
            8                     part located between the radiation source and the detectors                        
            9                     22. (Misner, col. 7, l. 66 to col. 8, l. 5).                                       
           10           24. Osemwota is directed to a process of non-invasive                                        
           11                     hematology, but also discloses performing calibrations using                       
           12                     blood samples. (col. 1, ll. 5-6).                                                  
           13           25. The Examiner held (Answer 8-9) that Osemwota  shows it to                                
           14                     be well known in the art that optical measurements are                             
           15                     initially calibrated using invasive samples.   We observe that                     
           16                     an invasive sample generally refers to drawing blood from                          
           17                     the patient to be tested.                                                          
           18           26.  Simons is directed to a dual-finger vital signs monitor that                            
           19                     uses a first radiation source and detector for blood pressure                      
           20                     measurement and a second radiation source and detector for                         
           21                     blood oxygenation measurement. (col. 2, ll. 1-14).                                 






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