Ex Parte Paul et al - Page 5


                 Appeal No.  2006-2037                                                          Page 5                  
                 Application No.  10/414,938                                                                            
                 e.g., the patient’s vascular system. Ragheb, column 1, lines 15-19.  Ragheb                            
                 discloses, “[h]owever, when such a device is introduced into and manipulated                           
                 through the vascular system, the blood vessel walls can be disturbed or injured.”                      
                 Ragheb, column 1, lines 22-24.  Ragheb discloses that the problems associated                          
                 with the introduction and manipulation of a medical device in a patient can be                         
                 solved by providing the controlled release of an agent, drug or bioactive material                     
                 into the location in the body where the device is positioned.  Ragheb, column 3,                       
                 lines 6-11.  In this regard, Ragheb                                                                    
                        discovered that the degradation of the agent, a drug or a bioactive                             
                        material that is applied to such a device can be avoided by positing                            
                        a coating layer on one surface of the device structure.  The agent,                             
                        drug or bioactive material is posited over at least a portion of the                            
                        coating layer, wherein the coating layer provides for a controlled                              
                        release of the bioactive material posited thereon.                                              
                 Ragheb, column 3, lines 11-18.                                                                         
                        For clarity, we reproduce Ragheb’s figure 1, which is a cross-sectional                         
                 view of one of Ragheb’s preferred embodiments2:                                                        











                 Accordingly, Ragheb discloses a device 10, which comprises a structure 12 that                         
                 is shaped and sized for introduction into a patient.  Ragheb, column 6,                                
                                                                                                                        
                 2 Ragheb, column 6, lines 3-4, “Fig. 1 is a cross-sectional view of a first preferred embodiment of    
                 the present invention.”                                                                                




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