Appeal 2006-2854
Application 10/348,165
microparticles to generate said microparticle populations (Br 2).
Representative independent claims 1 and 9, as presented in the Brief, appear
below:
1. A method for generating a plurality of microparticle populations of
different dye concentrations wherein dye is loaded into polymer
microparticles to generate said microparticle populations, comprising:
(a) providing:
(i) at least one first solvent in which the dye and the
microparticle polymer are soluble;
(ii) at least one tuning solvent in which the dye and the
microparticle polymer are not or only weakly soluble, said first and
tuning solvents being immiscible or at most partially miscible;
(iii) at least one third solvent in which the dye and the
microparticle polymer are not or only weakly soluble, said third
solvent being miscible with the first and tuning solvents;
(b) forming a plurality of suspensions of said polymer microparticles,
each in a designated volume of a mixture including the tuning solvent and
the third solvent;
(c) adding to said polymer microparticle suspension a solution
including the dye dissolved in said first solvent to form a homogeneous
solution in the mixture of the first, tuning and third solvents; and
(d) increasing the uptake of dye into the polymer microparticles in at
least one of said populations relative to another of said populations by
decreasing the solvency of the mixture of the first, tuning and third solvents
for the dye.
9. A method of producing dyed polymer microparticles comprising:
(a) providing:
2
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