Ex Parte Subramanyan et al - Page 11

                   Appeal No. 2006-3151                                                                                            
                   Application No. 10/767,679                                                                                      

                   compositions having a pH of 4.1 (see column 3, lines 60-65 and Table 2).”                                       
                   (Answer 18.)  The Examiner argues that “cosmetic products that are used for                                     
                   application to the skin” generally have a pH about 7, that is, neutral pH.                                      
                   (Id.)  Thus, “absent evidence to the contrary,” the Examiner takes the                                          
                   position that “Appellants’ personal care composition is also provided in a pH                                   
                   range about 7, such as in a range that is at least close to or even overlaps                                    
                   with the pH of from 3 to 10, as taught by Jokura.”  (Answer 19.)  The                                           
                   Examiner concludes that “as Jokura et al. teaches a pH range that is at least                                   
                   close to and/or overlaps with that of the instantly claimed composition                                         
                   having the ratio of partially to fully neutralized salt, it is considered that the                              
                   composition of Jokura et al. does indeed have an amount of ‘fully                                               
                   neutralized’ acid salt form present in the solution.”  (Id.)                                                    
                          The Examiner also argues that it would have been obvious “to vary                                        
                   and/or optimize the pH and/or the ratio of salt form to free acid form as                                       
                   taught by Jokura et al. (column 3, lines 50-65) and thus simultaneously vary                                    
                   and/or optimize the ratio of partially neutralized to fully neutralized salt.”                                  
                   (Id.)                                                                                                           
                          We conclude that the Examiner has set forth a prima facie case that                                      
                   the composition of claim 2 would have been obvious.  Jokura does not state                                      
                   that malonic acid is present as a half neutralized acid and as a fully                                          
                   neutralized acid in a molar ratio ranging from about 1000:1 to about 1:1000,                                    
                   respectively.  However, Jokura describes regulating “the pH value of the                                        
                   skin cosmetic . . . to pH 3 to 10, still [more] preferably to pH 3 to 9,” and                                   
                   exemplifies a pH of 4.1.  (Col. 3, ll. 60-63, & Table 2.)                                                       



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