Appeal 2006-3373
Application 09/919,504
1. A composition comprising,
one or more nucleic acid sequences selected from the group consisting
of oligonucleotides, antisense oligonucleotides, triplex DNA compounds,
ribozymes, and mixtures thereof; and
an octalock copolymer, wherein the octoblock copolymer has the
following formula:
wherein:
the mean aggregate molecular weight of the portion of the octablock
copolymer represented by polyoxypropylene is between about 5000 and
about 7000 Daltons;
a is a number such that the portion represented by the
polyoxyethylene constitutes between about 10% and about 40% of the
octablock copolymer by weight; and
b is a number such that the polyoxypropylene portion of the total
molecular weight of the octablock copolymer constitutes about 60% and
about 90% of the octablock copolymer by weight.
Claims 1-5, 8-13, 16-23, 26-31, 33-36, 38, and 41 stand rejected under
35 U.S.C. § 102(e) as being anticipated by Lemieux.1 In addition, claims 1,
6, 7, 9, 14, 15, 19, 24, 25, 27, 32, and 37 stand rejected under
35 U.S.C. § 103(a) as being unpatentable over the combination of Lemieux
and Emanuele.2 Claims 17, 33, 39, 40, and 42 stand rejected under 35
U.S.C. § 103(a) as being unpatentable over Lemiex. Finally, claims 1-5, 8-
1 Lemieux, U.S. Patent No. 6,359,054 B1, issued March 19, 2002.
2 Emanuele, U.S. Patent No. 5,674,911, issued October 7, 1997.
2
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