Appeal 2007-0532 Application 10/828,316 position that “the molecular weight of the instant application is within the matrix molecular weight used by [Sander] and Boyce” (Answer 12). The references also do not expressly disclose the pH range recited in the claims, nor does Boyce characterize the viscosity of the slurry or paste composition at 22° C and 37° C. Again, however, Appellants do not argue that either of these limitations distinguishes the claimed composition from the one suggested by the cited references. We also agree that the cited references would have suggested the composition of claim 26, which adds to claim 23 the limitation that the bone particles have a size range of 100 to 850 microns (i.e., 0.1 to 0.85 mm) and a concentration of 20-35% of the composition. Boyce teaches a composition having 5-100% bone particles and therefore teaches a concentration range that overlaps the one recited in claim 26. With respect to the particle size range, Boyce teaches that the “powdered bone particles can range in average particle size from about 0.05 to about 1.2 cm” (col. 4, ll. 56-58), i.e., 0.5 to 12 mm. Thus, the range of particle sizes taught by Boyce also overlaps the size range recited in claim 26. “[W]here there is a range disclosed in the prior art, and the claimed invention falls within that range, there is a presumption of obviousness.” Iron Grip Barbell Co., Inc. v. USA Sports, Inc., 392 F.3d 1317, 1322, 73 USPQ2d 1225, 1228 (Fed. Cir. 2004). Appellants argue that Boyce teaches a “shaped hardened load bearing osteoimplant bone structure formed of compressed bone particles and not a . . . formable putty composition” (Br. 5, 14). This argument is not persuasive. Boyce teaches that a composition having the consistency of a slurry or putty is formed, comprising all of the 9Page: Previous 1 2 3 4 5 6 7 8 9 10 11 12 Next
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