Ex Parte Jacobs et al - Page 8

              Appeal 2007-0539                                                                     
              Application 10/264,026                                                               

              believing that the products of the applicant and the prior art are the same, the     
              applicant has the burden of showing that they are not.”  In re Spada, 911            
              F.2d 705, 708, 15 USPQ2d 1655, 1658 (Fed. Cir. 1990).  Likewise, “[w]here            
              a product-by-process claim is rejected over a prior art product that appears to      
              be identical, although produced by a different process, the burden is upon           
              the applicants to come forward with evidence establishing an unobvious               
              difference between the claimed product and the prior art product.”  In re            
              Marosi, 710 F.2d 799, 803, 218 USPQ 289, 292-93 (Fed. Cir. 1983).                    
              Shifting the burden under these circumstances is reasonable because of “the          
              PTO’s inability to manufacture products or to obtain and compare prior art           
              products.”  In re Best, 562 F.2d 1252, 1255, 195 USPQ 430, 433-34 (CCPA              
              1977).                                                                               
                    The issue raised by this appeal, then, is whether the Examiner has             
              provided a reasonable basis for shifting the burden to Appellants to establish       
              that the prior art pseudopterosin compositions do not contain pseudopterosin         
              compounds obtainable from Symbiodinium spp., and/or that the prior art               
              compositions contain animal impurities.                                              
                    We find that the references cited by the examiner describe                     
              pseudopterosin compositions containing pseudopterosin compounds, and                 
              synthetic derivatives thereof, of the same classes obtained from                     
              Symbiodinium spp.  Moreover, because the pseudopterosin compounds were               
              isolated and purified before being incorporated into compositions, we find           
              that the Examiner has established a reasonable basis for concluding that the         
              prior art compositions are free of animal impurities.  Therefore, we find that       
              the Examiner has provided a reasonable basis for shifting the burden to              


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