Ex Parte Crabtree et al - Page 10

                Appeal 2007-1040                                                                               
                Application 09/960,708                                                                         
                presented the evidence necessary to establish a prima facie case of                            
                obviousness.                                                                                   
                      In response, Appellants assert that Jiang’s model is not designed to                     
                determine the effect of FK506 on established tumor growth (Br. 16).                            
                Instead, Appellants assert that Jiang’s studies are designed to determine the                  
                ability of an agent to inhibit papilloma formation in a mouse model (id.).                     
                We are not persuaded by Appellants’ argument.                                                  
                      Claim 47 is not drawn to the treatment of “established tumor growth.”                    
                Instead, claim 47 is drawn to the inhibition of tumor growth in a host having                  
                a neoplastic disease condition.  According to Appellants’ Specification,                       
                treatment “includes situations where the pathological condition, or at least                   
                symptoms associated therewith, are completely inhibited, e.g.[,] prevented                     
                from happening . . . .”  Jiang teaches that the topical administration of                      
                FK506 or cyclosporin A inhibits tumor (papilloma) formation in a mouse                         
                model (Jiang 69, col. 2, ll. 18-20 and 23-24; Br. 16).                                         
                      For the foregoing reasons, we find no error in the rejection of claim                    
                47 under 35 U.S.C. § 103 as being unpatentable over the combination of                         
                Jiang and Flanagan.  Accordingly, the rejection is affirmed.                                   

                                               CONCLUSION                                                      
                      In summary, we reverse the rejection under 35 U.S.C. § 102(b) and                        
                the rejection of claims 36-44 under 35 U.S.C. § 103.  We affirm the rejection                  
                of claims 46 and 47 under 35 U.S.C. § 103.                                                     





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