Appeal 2007-1139
Application 10/052,664
The Examiner relies on the following references:
Peer Bork et al., “Predicting functions from protein sequences-where
are the bottlenecks?” 18 Nature Genetics, 313-318 (1998).
Peer Bork et al., “Sequences and topology-Deriving biological
knowledge from genomic sequences” 8 Current Opinion in Structural
Biology, 331-332 (1998).
Karp “Editorial-What We Do Not Know About Sequence Analysis
and Sequence Databases” 14(9) Bioinformatics, 753-754 (1998).
We reverse.
BACKGROUND
According to the Specification,
Phosphorous plays an important role in membrane
structure, transport and energy storage. At normal
physiological pH (e.g. pH of 7.4), inorganic phosphate (Pi) in
plasma is made up of a 4: 1 mixture of HPO42- and H2PO4-. Of
the 700 g of phosphorous present in the body, 0.1 % is present
in the extracellular fluid in a freely diffusible form. The plasma
level of Pi is maintained through control of Pi absorption in the
small intestine, under the influence of vitamin D, and Pi
excretion in the kidney, under the influence of parathyroid
hormone.
Absorption of Pi requires transepithelial transport. A
critical step of transepithelial transport of Pi is the uptake of Pi
into epithelial cells. Pi uptake is accomplished by sodium
phosphate co-transporters present on the apical surface of
appropriate epithelial cells, e.g. intestinal and renal epithelial
cells. A variety of sodium phosphate co-transporters have been
identified to date, including: NaPi-1 (rabbit); NPTl (human);
Npt 1 (mouse); NaPi-2 (rat); NaPi-3 (human); NaPi-4
(opossum); NaPi-5 (flounder); NaPi-6 (rabbit); NaPi-7 (mouse);
and NaPi of NBL-1 cells (bovine).
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