Ex Parte Hu et al - Page 5

                Appeal 2007-1148                                                                             
                Application 10/078,592                                                                       

                public” and “provide[s] a well-defined and particular benefit to the public.”                
                See Fisher, 421 F.3d at 1371, 76 USPQ2d at 1230.  Therefore, the                             
                Specification does not disclose a specific and substantial utility for the                   
                claimed invention, as required by § 101.                                                     
                      Appellants argue that the amino acid sequence of SEQ ID NO:2                           
                “shares nearly 100% identity over an extended length” with the amino acid                    
                sequence disclosed and claimed in the Beasley patents, including the                         
                putative metalloprotease domain (Br. 4).  Appellants argue that “[a]s the                    
                United States Patent and Trademark Office has clearly established that the                   
                sequence claimed in U.S. Patent Nos. 6,461,850 and 6, 638,751 has a                          
                patentable utility, there can be no question that Appellants’ sequence . . .                 
                must also have a patentable utility” (id.)                                                   
                      We disagree.  The issue is not whether the protein of SEQ ID NO:2,                     
                or a nucleic acid encoding it, “ha[s] a patentable utility” in some                          
                metaphysical sense; the issue is whether the instant Specification discloses a               
                utility adequate to support § 101.  The fact that Beasley’s disclosure was                   
                found to support patentability is irrelevant.                                                
                      In addition, the Beasley patents issued after the effective filing date of             
                this application.  While post-filing evidence can be relied on to show the                   
                accuracy of a statement in the Specification, it cannot be used to supplement                
                the Specification’s disclosure.  See In re Hogan, 559 F.2d 595, 605, 194                     
                USPQ 527, 537 (CCPA 1977) (“[U]se of later publications as evidence of                       
                the state of art existing on the filing date of an application” is acceptable).              
                Thus, the Beasley patents can be relied on only to confirm the                               
                Specification’s statement that SEQ ID NO:2 is a zinc-dependent                               


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