Appeal 2007-1369
Application 10/032,257
a body comprising a silicon substrate and a glass substrate positioned
together,
a cutter having a tapered opening with a sharp edge for cutting the
tissue, said cutter located in said silicon substrate,
a specimen chamber located in said silicon substrate and said glass
substrate immediately below said cutter, said specimen chamber positioned
to directly receive the tissue cut by said cutter,
a specimen treatment and analysis chamber located in said silicon
substrate and said glass substrate abutting and connected directly to said
specimen chamber and located adjacent said specimen chamber,
an analysis unit in said specimen treatment and analysis chamber,
a PCR reaction chamber located in said silicon substrate and said
glass substrate directly abutting and connected directly to said specimen
treatment and analysis chamber, said PCR reaction chamber constructed to
receive the tissue from said specimen treatment and analysis chamber, and
a heating unit in said body adjacent said PCR reaction chamber.
The Examiner relies upon the following references as evidence of
obviousness:
Pourahmadi WO 99/33559 Jul. 8, 1999
Krulevitch ('217) US 5,985,217 Nov. 16, 1999
Krulevitch ('474) US 6,219,474 B1 Nov. 20, 2001
Appellants' claimed invention is directed to a microfabricated biopsy
and analysis instrument for tissue. The instrument consists of, inter alia, a
specimen treatment and analysis chamber located in silicon and glass
substrates positioned together, and a PCR reaction chamber also located in
the silicon and glass substrates. The PCR reaction chamber directly abuts
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