Ex Parte Hage et al - Page 13

                Appeal 2007-1396                                                                             
                Application 10/375,235                                                                       
                discouraged from following the path set out in the reference, or would be led                
                in a direction divergent from the path that was taken by the applicant.”                     
                (quoting In re Gurley, 27 F.3d 551, 553 [31 USPQ2d 1130, 1131], (Fed. Cir.                   
                1994)); In re Fulton, 391 F.3d 1195, 1201, 73 USPQ2d 1141, 1145-46 (Fed.                     
                Cir. 2004) (prior art “disclosure does not criticize, discredit, or otherwise                
                discourage the solution claimed”).                                                           
                      In this respect, Appellants’ explanation of the mechanisms in the                      
                pathway leading from the triglycerides in oily stains to activation of the                   
                resulting hydroperoxide through the action of the lipase, lipoxidase, and                    
                transition metal catalyst does not establish non-obviousness.  Cf., e.g., In re              
                Woodruff, 919 F.2d 1575, 1577, 16 USPQ2d 1934, 1936 (Fed. Cir. 1990);                        
                W.L. Gore & Assocs. v. Garlock, Inc., 721 F.2d 1540, 1548, 220 USPQ 303,                     
                309 (Fed. Cir. 1983) (“[I]t is . . . irrelevant that those using the invention               
                may not have appreciated the results[,] . . . [otherwise] it would be possible               
                to obtain a patent for an old and unchanged process. [Citations omitted.]”);                 
                In re Skoner, 517 F.2d 947, 950, 186 USPQ 80, 83 (CCPA 1975).  Indeed,                       
                the action of lipases on the triglycerides in oily stains to form                            
                polyunsaturated fatty acids was well known to one of ordinary skill in this                  
                art; Baeck discloses lipoxidases oxidize polyunsaturated fatty acids to their                
                corresponding hydroperoxide; and Hermant and Perkins disclose activating                     
                hydroperoxides with an “air mode” transition metal catalyst.                                 
                      Appellants contend the evidence in Specification Examples 1 and 1a                     
                and Examples 4 and 4a establishes the combination of catalyst,                               
                lipoxygenase, and lipase exhibits a synergistic effect.  On this record, we                  
                agree with the Examiner that Appellants have not established that the results                
                reported are unexpected by one of ordinary skill in the art.  Indeed,                        

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