Ex Parte Kashima et al - Page 9

               Appeal 2007-1627                                                                            
               Application  09/870,009                                                                     

                      is  embedded  in  a  portion  other than  said  gene  portion  and                   
                      comprises source identification information of said                                  
                      predetermined gene.                                                                  
               (Answer 7.)                                                                                 
                      Similarly, the Examiner reasons that Arnot discloses                                 
                      genomic DNA including the CS gene of Plasmodium                                      
                      falciparum . . . which represents DNA including a                                    
                      predetermined  gene,  . . .  along  with  the  5’  flanking  region                  
                      wherein the flanking region represents a portion which is other                      
                      than the gene portion. . . .  Figure 1 shows two types of tandem                     
                      repeat  primers  with  TAG  sequences  bound  to  the  genomic                       
                      sequence. . . . [T]he primers represent not naturally occurring                      
                      nucleotide  sequences  and  the  flanking  primer  represents  a                     
                      sequence  embedded  in portion  other  than  said  gene  portion                     
                      which identifies source of predetermined gene.                                       
               (Id. at 9-10.)                                                                              
                      Appellants argue that “nowhere does Lizardi teach or suggest DNA                     
               that includes the gene for Huntington’s chorea and the OCP [open-circle                     
               probe].  Instead, Lizardi teaches that the OCP may be used to replicate a                   
               target sequence to detect a gene for Huntington’s chorea in a sample                        
               mixture” (Appeal Br. 13).  With regard to Arnot, Appellants argue that                      
               “Arnot does not teach or suggest a nucleotide sequence which is not                         
               naturally occurring in said DNA and which is embedded in said portion                       
               which is other than said gene portion, and comprises source identification                  
               information which identifies a source of said predetermined gene in said                    
               gene portion” (id. at 27).                                                                  
                      We agree with Appellants that the Examiner has not adequately                        
               shown that either Lizardi or Arnot teaches all of the limitations of the                    
               claims.  Claim 5, for example, is directed to DNA that comprises a gene                     


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