Appeal 2007-2400
Application 10/418,182
individually; and then through each of the possible
combinatorial variations of the CDRs (pairs, triad, tetrads, etc.).
(Id. at 15-16.)
The libraries are disclosed to be useful as research tools (id. at 17-18).
DISCUSSION
1. CLAIMS
Claims 1-9 are pending and on appeal. The claims have not been
argued separately and therefore stand or fall together. 37 C.F.R.
§ 41.37(c)(1)(vii) (2006). Claim 1 is representative and reads as follows:
1. A library for an immunoglobulin of interest, comprising mutated
immunoglobulins of interest wherein a single predetermined amino acid has
been substituted in at least one position in at least one complementarity-
determining region of the immunoglobulin of interest, the library including
subset libraries comprising:
a) a subset library comprising the immunoglobulin of interest,
b) subset libraries comprising mutated immunoglobulins in which the
predetermined amino acid has been substituted in at least one position
in one of the six complementarity-determining regions of the
immunoglobulin, with one subset library for each of the six
complementarity-determining regions, thereby totaling 6 subset
libraries;
c) subset libraries comprising mutated immunoglobulins in which the
predetermined amino acid has been substituted in at least one position
in two of the six complementarity-determining regions, with one
subset library for each of the possible combinations of two of the six
complementarity-determining regions, thereby totaling 15 subset
libraries;
d) subset libraries comprising mutated immunoglobulins in which the
predetermined amino acid has been substituted in at least one position
in three of the six complementarity-determining regions, with one
3
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