Ex Parte Perricone - Page 2

               Appeal 2007-3935                                                                            
               Application 10/625,244                                                                      
               containing an amount of benfotiamine effective to reduce the quantity of                    
               glycated proteins in said skin cells, in a dermatologically acceptable carrier,             
               to skin tissue.                                                                             
               11. A method for the treatment of glycation in cells of the skin                            
               comprising: applying a composition acting directly upon said skin cells                     
               containing an amount of benfotiamine effective to reduce the quantity of                    
               glycated proteins in said skin cells, in a dermatologically acceptable carrier,             
               to affected skin tissue.                                                                    
               12. A method for the treatment of damage to the cells of the skin due to                    
               glycation comprising: applying a composition acting directly upon said skin                 
               cells containing an amount of benfotiamine effective to reduce formation of                 
               glycated proteins in said cells, in a dermatologically acceptable carrier, to               
               skin tissue.                                                                                
               13. A method for the treatment of aging of the cells of the skin due to                     
               glycation comprising: applying a composition acting directly upon said skin                 
               cells containing an amount of benfotiamine effective to reduce quantity of                  
               glycated proteins in said cells, in a dermatologically acceptable carrier, to               
               affected skin tissue.                                                                       
               15. A method in accordance with claims 10, 11, 12, or 13, wherein the                       
               composition contains from about .05% to about 70% by weight                                 
               benfotiamine.                                                                               


                      The Examiner relies upon the following references:                                   
                      Woerwag (as translated) DE 41 10087 A1 Oct. 1992                                     
                      Runge US 6,261,598 B1 Jun. 17, 2001                                                  
                      “Questions & Answers about … Arthritis and Rheumatic Diseases”,                      
               02-4999 National Institute of Arthritis and Musculoskeletal and Skin                        
               Diseases (NIAMS), 1-34(2002),                                                               
               http://www.niams.nih.gov/hi/topics/arthritis/artrheu.htm.                                   

                      We affirm.                                                                           

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