Ex Parte Perricone - Page 5

               Appeal 2007-3935                                                                            
               Application 10/625,244                                                                      
                      The Federal Circuit found that the prior art anticipated the above                   
               referenced claim, along with other claims to particular skin benefits achieved              
               by applying the composition to the skin.  Id. at 1378-79.  Specifically, the                
               court found that all skin is subject to damage or aging by oxygen-containing                
               free radicals or oxidative generation of biologically active metabolites, thus              
               all that was required was application of the composition to the skin.  Id. at               
               1379-80.                                                                                    
                      In the instant case, all skin is subject to glycation, with the resultant            
               loss of skin elasticity and the breakdown of collagen.  Thus the benefit stated             
               in the preamble of the claims, of reduction or treatment of glycation,                      
               treatment of damage of cells due to glycation, or treatment of aging of cells               
               due to glycation, naturally flows from the method of applying the                           
               composition of Runge to the skin, see, e.g., Perricone, 432 F.3d at 1378, and               
               thus Runge anticipates the subject matter of independent claims 10-13, 21,                  
               22, 24-26, as well as dependent claim 23.                                                   
                      Claim 14 requires an additional ingredient, such as ascorbic acid.  As               
               Runge teaches that the composition may contain ascorbic acid, (col. 2, ll. 53-              
               61), Runge also anticipates the method of claim 14.                                         
                      Claim 15 requires that the composition contain from about 0.05% to                   
               about 70% by weight benfotiamine; claim 16 requires that the composition                    
               contain from about 5% to about 20% by weight benfotiamine; claim 17                         
               requires that the composition contain from about 0.05% to about 5% by                       
               weight benfotiamine; and claim 18 requires that the composition contain                     
               from about 0.25% to about 7% by weight benfotiamine.  As Runge teaches                      
               that the additional ingredient, i.e., benfotiamine, may be present in an                    
               amount of of 0.01% to 40% by weight, it anticipates the methods of claims                   

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