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                    The parties hereto have executed this Agreement as                
               a sealed instrument and this Agreement becomes duly                    
               effective, as of the date first written above.                         
          MEDCHEM PUERTO RICO, INC.                                                   
          By:    /s David A. Swann                                                    
          Title: CEO                                                                  
          ALCON (PUERTO RICO) INC.                                                    
          By:    /s                                                                   
          Title: Vice President                                                       
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