Ex parte MURRER et al. - Page 13




                                                 Appeal No. 95-2603                                                                                                                                                                                                                                                                                                                                                                    
                                                 Application 07/915,871                                                                                                                                                                                                                                                                                                                                                                


                                                 +)))))))))))))))))))))))))))))))))))))))))))))))))))))))),                                                                                                                                                                                                                                                                                                                            
                                                 *                                                        *                                                                                                                                                                                                                                                                                                                            
                                                 *  11  10  9  8  7   6  5   4   3  2   1   14 13  12     *                                                                                                                                                                                                                                                                                                                            
                                                 .))N)))CH )CH )NH)CH )CH )CH )NH))CH )CH )NH))CH )CH )CH ))))-                                                                                                                                                                                                                                                                                                                        
                                                                               2             2                       2             2            2                         2            2                        2             2             2                                                                                                                                                                                          
                                                 *                                                                                                                                                                                                                                                                                                                                                                                     
                                                 CH2                                                                                                                                                                                                                                                                                                                                                                                   
                                                 *                                                                                                                                                                                                                                                                                                                                                                                     
                                                 CH2                                                                                                                                                                                                                                                                                                                                                                                   
                                                 *                                                                                                                                                                                                                                                                                                                                                                                     
                                                 +))N)))CH )CH )NH)CH )CH )CH )NH))CH )CH )NH))CH )CH )CH )))),                                                                                                                                                                                                                                                                                                                        
                                                                               2             2                       2             2            2                         2            2                        2             2             2                                                                                                                                                                                          
                                                 *  11' 10' 9' 8' 7'  6' 5'  4'  3' 2'  1'  14'13' 12'    *                                                                                                                                                                                                                                                                                                                            
                                                 *                                                        *                                                                                                                                                                                                                                                                                                                            
                                                 .))))))))))))))))))))))))))))))))))))))))))))))))))))))))-                                                                                                                                                                                                                                                                                                                            
                                                                                                   11,11'-(1,2-ethanediyl)bis-1,4,8,11-tetraazacyclotetradecane                                                                                                                                                                                                                                                                        
                                                                                                                                                             (when viewed from the bottom)                                                                                                                                                                                                                                             




                                                 Ciampolini describes the compound which appellants identify as                                                                                                                                                                                                                                                                                                                        
                                                 11,11'-(1,2-ethanediyl)bis-1,4,8,11-tetraazacyclotetradecane,                                                                                                                                                                                                                                                                                                                         
                                                 because Ciampolini describes a process (page 3528, reaction                                                                                                                                                                                                                                                                                                                           
                                                 scheme at the top of the page) for making Compound 2 (page                                                                                                                                                                                                                                                                                                                            
                                                 3527, col. 1) which has a structural formula identical to                                                                                                                                                                                                                                                                                                                             
                                                 either formula set out above.  Ciampolini also describes other                                                                                                                                                                                                                                                                                                                        
                                                 bis-cyclams containing bridging groups.  See Compounds 3, 4, 5                                                                                                                                                                                                                                                                                                                        
                                                 and 6.                                                                                                                                                                                                                                                                                                                                                                                
                                                                          Compounds 2, 3, 4, 5 and 6 were converted into nickel(II)                                                                                                                                                                                                                                                                                                    
                                                 and copper(II) complexes.  Electrochemical parameters were                                                                                                                                                                                                                                                                                                                            

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