Ex parte MURRER et al. - Page 11




          Appeal No. 95-2603                                                          
          Application 07/915,871                                                      


          ions is this particular linking of two cyclam moieties.                     
          Therefore there is no motivation or suggestion to make the                  
          proposed molecular modifications needed to arrive at the                    
          claimed active ingredients.  See In re Lalu, 747 F.2d 703,                  
          705, 223 USPQ 1257, 1258 (Fed. Cir. 1984) and compare In re                 
          Dillon, 919 F.2d 688, 16 USPQ2d 1897 (Fed. Cir. 1990) (en                   
          banc), cert. denied, 500 U.S. 904 (1991).  Thus the rejection               
          of claims 7, 8 and 23 under § 103 in view of Ciampolini, as                 
          interpreted and applied by the examiner, cannot be sustained.               
               For the foregoing reasons, the examiner’s new ground of                
          rejection under § 103 is reversed.                                          

               D.  The Rejections Under 37 CFR § 1.196(b)                             
               The first new ground of rejection involves claim 23 under              
          35 U.S.C. § 102(b) as anticipated by Ciampolini.  Compound 2                
          on page 3527 of Ciampolini is believed to be identical to the               
          active ingredient 11,11'-(1,2-ethanediyl)bis-1,4,8,11-                      
          tetraazacyclo-tetradecane recited in claim 23.  Initially, we               
          find that appellants' use of the designation 11,11'- in                     
          identifying 11,11'-(1,2-ethanediyl)bis-1,4,8,11-                            
          tetraazacyclotetradecane is somewhat odd.  The compound named               

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