Ex parte MURRER et al. - Page 14




                     Appeal No. 95-2603                                                                                                                                                
                     Application 07/915,871                                                                                                                                            


                     measured for each nickel and copper complex (page 3529, col.                                                                                                      
                     1, table 1).  The complexes were made according to the                                                                                                            
                     following process (page 3529, col. 1, third full paragraph):                                                                                                      
                                                     *** [C]omplexes were obtained *** by mixing                                                                                       
                                           ethanolic solutions of the ligand and of the metal                                                                                          
                                           perchlorate (1:2 molar ratio) and allowing to reflux                                                                                        
                                           for 30 min.  The complexes, recrystallized from                                                                                             
                                           methanol, gave satisfactory C, H, N elemental                                                                                               
                                           analysis.                                                                                                                                   
                                The "ligand" is any one of Compounds 2, 3, 4, 5 and 6.                                                                                                 
                     An ethanolic solution of the ligand is a solution of the                                                                                                          
                     ligand in ethanol.  Ethanol is a known pharmaceutical                                                                                                             
                     carrier.   The utility recited in the preamble of appellant's8                                                                                                                                                
                     claim, i.e., activity "against HIV-infected cells in in vitro                                                                                                     
                     tests," means that purity for appellants' pharmaceutical                                                                                                          
                     composition is not as much a concern as it might be in a                                                                                                          
                     pharmaceutical administered to a human.  Hence, Ciampolini's                                                                                                      
                     description of a mixture of the ligand which is Compound 2 and                                                                                                    
                     ethanol is a description of a species within the scope of                                                                                                         

                                8    See, for example, Smiles et al., U.S. Patent No. 4,959,210, column 2, lines                                                                       
                     44-46 (copy attached to this decision).                                                                                                                           
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