Ex parte MURRER et al. - Page 16




                     Appeal No. 95-2603                                                                                                                                                
                     Application 07/915,871                                                                                                                                            


                     solution of the biscyclam compound (page 2671, left column)                                                                                                       
                     ("1 equiv of Ni(NO )  was added to an aqueous solution of                                                                                                         
                                                            3  2                                                                                                                       
                     biscyclam at pH7" and "biscyclam" is Compound 2 (page 2671,                                                                                                       
                     column 2)).  Since water is a known pharmaceutical carrier ,                                                                 9                                    
                     the claimed composition is anticipated by Fabbrizzi, even                                                                                                         
                     though the utility disclosed by Fabbrizzi is different than                                                                                                       
                     appellants’ utility.  See Titanium Metals Corp. v. Banner, 778                                                                                                    
                     F.2d 775, 782, 227 USPQ 773, 779 (Fed. Cir. 1985); In re                                                                                                          
                     Wilder, 563 F.2d at 460-61, 195 USPQ at 429-30.                                                                                                                   
                                Claims 7 and 23 are rejected under § 102(b) as                                                                                                         
                     anticipated by Barefield.  As characterized on page 3 of the                                                                                                      
                     specification, Barefield discloses the 2,2'-bicyclam                                                                                                              
                     derivative of claims 7 and 23 (compound 2 on page 303).                                                                                                           
                     Barefield teaches that this “octa-amine” (bicyclam) is very                                                                                                       
                     insoluble in water and most organic solvents (see the footnote                                                                                                    
                     on page 303).  To recognize this insolubility, it is more                                                                                                         
                     likely true than not, that Barefield  intermixed these                                                                                                            
                     materials, thus creating a composition of bicyclam and water                                                                                                      
                     which is one of the compositions embraced by appealed claim                                                                                                       


                                9    Ibid.                                                                                                                                             
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