Ex parte MURRER et al. - Page 5




          Appeal No. 95-2603                                                          
          Application 07/915,871                                                      


          § 1.196(b), we enter the following new grounds of rejection:                
               (1) claim 23 is rejected under 35 U.S.C. § 102(b) as                   
          anticipated by Ciampolini;                                                  
               (2) claims 8 and 23 are rejected under 35 U.S.C. § 102(b)              
          as anticipated by Fabbrizzi;                                                
               (3) claims 7 and 23 are rejected under 35 U.S.C. § 102(b)              
          as anticipated by Barefield; and                                            
               (4) claim 23 is rejected under 35 U.S.C. § 112, first                  
          paragraph, in view of Ciampolini, as being based upon a                     
          specification which fails to enable a person skilled in the                 
          art to make the invention as broadly as claimed, i.e., the                  
          enabling disclosure in appellants’ specification is not                     
          commensurate in scope with the breadth of claim 23.                         

                                       OPINION                                        
               A.  The § 103 Rejection over Lehn                                      
               Claim 23 recites a pharmaceutical composition comprising               
          an active ingredient selected from a group of eleven                        
          compounds  and a pharmaceutically acceptable carrier.4                                                                  

               4Eleven "compounds" are recited in claim 23.  The first, "bicyclam" is a
          recitation of a genus of compounds.  The other ten "compounds" are specific compounds.
          The genus "bicyclam" encompasses the 2,2'-bicyclam and 6,6'-bicyclam isomers of claims 7
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