Ex parte MURRER et al. - Page 2




                     Appeal No. 95-2603                                                                                                                                                
                     Application 07/915,871                                                                                                                                            


                     all the claims remaining in this application.                                                                                                                     


                                According to appellants, the invention is concerned with                                                                                               
                     pharmaceutical compositions comprising bicyclam or related                                                                                                        
                     polyazacyclohexa- or tetra-decanes, active against HIV-                                                                                                           
                     infected cells in vitro  (brief, page 1).         2                                                                                                               
                                Claim 23 has been amended by an amendment filed with the                                                                                               
                     reply brief dated Dec. 28, 1994 (Paper No. 19), and entered as                                                                                                    
                     noted by the examiner in the Supplemental Answer dated Mar.                                                                                                       
                     13, 1995 (Paper No. 20).  Claims 23, 7 and 8 are reproduced                                                                                                       
                     below:                                                                                                                                                            

                                           23.  A pharmaceutical composition which is active                                                                                           
                     against HIV-infected cells in in vitro tests comprising, as                                                                                                       
                     active ingredient, a compound selected from the group                                                                                                             
                     consisting of bicyclam                                                                                                                                            
                     3,3'-bis-1,5,9,13-tetraazacyclohexadecane                                                                                                                         
                     3,3'-bis-1,5,8,11,14-pentaazacyclohexadecane                                                                                                                      
                     5,5'-bis-1,4,8,11-tetraazacyclotetradecane                                                                                                                        
                     2,5'-bis-1,4,8,11-tetraazacyclotetradecane                                                                                                                        


                                2    The grandparent of this application, Application No. 07/454,418, has become                                                                       
                     U.S. Patent No. 5,021,409, with claims directed to a method of treating infection by a                                                                            
                     retrovirus.                                                                                                                                                       
                                                                                          2                                                                                            





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