HUANG et al. V. PRASIT et al. - Page 5





                                                                                     
                                                                                     


               X is O or S;                                                           
                    wherein R  is selected from aryl and heteroaryl;1                                                        
               wherein R  is optionally substituted with one or more1                                                             
               radicals selected from halo, alkylthio,                                
               alkylsulfinyl, alkyl, alkylsulfonyl, cyano,                            
               carboxyl, alkoxycarbonyl, aminocarbonyl, N-                            
               alkylaminocarbonyl, N-arylamino-carbonyl, N,N-                         
               dialkylaminocarbonyl, N-alkyl-N-arylaminocarbonyl,                     
               haloalkyl, hydroxyl, alkoxy, hydroxyalkyl,                             
               haloalkoxy, amino, N-alkylamino, N,N-dialkylamino,                     
               nitro and alkylcarbonylamino,                                          
                    wherein                  R  is aryl substituted2                                       
               with a                        radical selected from                    
               alkylsulfony                  l and aminosulfonyl; and                 
                    wherein                  R  is one or more3                                       
               radicals                      selected from hydrido,                   
               halo, alkyl, and haloalkyl;                                            
                    or a pharmaceutically-acceptable salt thereof.                    

          The Prasit compound:                                                        
                    A compound of the formula                                         







                                          5                                           





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