HUANG et al. V. PRASIT et al. - Page 6













                    or a pharmaceutically acceptable salt thereof                     
               wherein:                                                               
                    X is O or S,                                                      
                    R  is selected from the group consisting of1                                                                
                         (a)  S(O) CH ,                                               
                                  2  3                                                
                         (b)  S(O) NH ,                                               
                                  2  2                                                
                         (c) S(O) NHCOCF ,                                            
                                  2      3                                            
                         (d) S(O)(NH)CH ,                                             
                                        3                                             
                         (e) S(O)(NH)NH ,                                             
                                        2                                             
                         (f) S(0)(NH)NHCOCF3,                                         
                         (g) P(O)(CH )OH, and                                         
                                     3                                                
                         (h) P(O)(CH )NH ,                                            
                                     3   2                                            
                    R  is selected from the group consisting of2                                                                
                         (a) C  alkyl,                                                
                               1-6                                                    
                         (b) C  cycloalkyl,                                           
                               3-7                                                    
                         (c) mono- or di-substituted phenyl or                        
               napthyl wherein the substituent is selected from the                   
               group consisting of                                                    


                              (1) hydrogen,                                           
                              (2) halo, including F, Cl, Br, I,                       
                              (3) C  alkoxy,                                          
                                    1-6                                               
                              (4) C  alkylthio,                                       
                                    1-6                                               
                                          6                                           





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