Ex Parte Rosengart et al - Page 7


                 Appeal No.  2007-0531                                                          Page 7                   
                 Application No.  10/341,679                                                                             
                                                                                                                        
                 The rejections based solely, or in-part, on the combination of Isner and Tischer:                       
                        In our opinion the combination of Isner and Tischer fails to teach injection                     
                 of an adenoviral vector comprising VEGF121 DNA directly to the internal surface                         
                 of the heart.  The Examiner relies on Wolff, Kovesdi, French and Ullrich to reach                       
                 limitations of dependent claims.  See Answer, pages 9-14.  While the Examiner                           
                 relies on French, the emphasis Examiner places on French is different than that                         
                 set forth below.  Accordingly, we vacate the pending rejections over the                                
                 combination of Isner and Tischer (alone or in combination with Wolff, French,                           
                 Kovesdi and Ullrich) in favor of the following new grounds of rejection.                                
                        Accordingly,                                                                                     
                                • the rejection of claims 1, 3, 6, 10, 19 and 22 under 35 U.S.C.                         
                                   § 103 as being unpatentable over the combination of Isner and                         
                                   Tischer is vacated;                                                                   
                                • the rejection of claims 1 and 12-18 under 35 U.S.C. § 103 as                           
                                   being unpatentable over the combination of Isner, Tischer and                         
                                   Kovesdi is vacated;                                                                   
                                • the rejection of claims 1 and 19-21 under 35 U.S.C. § 103 as                           
                                   being unpatentable over the combination of Isner, Tischer, Wolff                      
                                   and French is vacated; and                                                            
                                • the rejection of claims 1 and 22-23 under 35 U.S.C. § 103 as                           
                                   being unpatentable over the combination of Isner, Tischer and                         
                                   Ullrich is vacated.                                                                   

                                          NEW GROUNDS OF REJECTION                                                       
                 FACTS:                                                                                                  
                        French teaches:                                                                                  
                                1. that in the field of cardiology, much interes has focused on                          
                                   developing techniques to introduce recombinant genes directly                         





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