Appeal 2007-2955
Application 10/190,425
5. “[T]he probes are attached in a pre-determined spatial array of
arbitrary shape. The array may comprise a plurality of different probes,
which are patterned in a pre-determined manner, including duplicates of
single probe types” (Spec. ¶ 23).
6. “Binding probes of interest include antibodies and fragments thereof,
which may bind, for example, cell surface antigens; adhesion molecules;
extracellular matrix components; . . . etc.” (Spec. ¶ 13). Also, “[p]olypeptide,
glycoprotein[ ], and proteoglycan[ ] binding probes are of particular interest,
including those found in extracellular matrix” (id. at ¶ 33).
Taylor
7. Taylor teaches that “a living cell [ ] comprises a complex organization
of biological components [and] has a . . . multitude of potential interactions
with a variety of substances, for example DNA, RNA, cell surface proteins,
intracellular proteins and the like” (Taylor, col. 2, ll. 8-12).
8. “Because a typical target for drug action is with and within the cells of
the body, cells themselves can provide a useful screening tool in drug
discovery” (Taylor, col. 2, ll. 12-14), and “[s]creening drug candidates
according to their interaction with living cells, prior to animal studies, can
reduce the number of animals required in subsequent drug screening
processes” (id. at col. 1, ll. 36-39 (emphasis added)).
9. “High throughput screening of nucleic acids and polypeptides has
been achieved through a technique known as combinatorial chemistry”
(Taylor, col. 1, ll. 47-49), but “[t]he information provided by an array of
either nucleic acids or amino acids . . . is limited” (id. at col. 2, ll. 3-4). “It
thus would be most useful to have a high throughput . . . screening device to
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