Appeal 2007-2955
Application 10/190,425
capable of binding a particular expression product . . . of a cell or population
of cells . . . and (ii) the array comprises a plurality of different protein-
capture agents” (Wagner, col. 2, l. 63 to col. 3, l. 7).
21. “Numerous materials are suitable for use as a substrate in the array[s]
. . . [including] silicon, silica, quartz, glass, controlled pore glass, [etc.]”
(Wagner, col. 13, ll. 59-63).
22. “Antibodies or antibody fragments are highly suitable as protein-
capture agents” (Wagner, col. 4, ll. 56-57).
23. “[P]roteins such as antibodies . . . are sensitive to the physical and
chemical properties of [ ] support materials” and “are preferably kept
hydrated” (Wagner, col. 2, ll. 39-41).
24. “An ‘organic thinfilm’ is a thin layer of organic molecules . . . applied
to a substrate” (Wagner, col. 7, ll. 57-58), and “[a] hydrogel may [ ]
compose an organic thinfilm” (id. at col. 8, ll. 27-28).
25. “Inkjet printer heads provide [an] option for patterning . . . molecules .
. . on the surface of the substrate or coating” (Wagner, col. 16, ll. 45-49).
Belov
26. Belov describes “a rapid, simple procedure, which enables concurrent
determination of 50 or more CD antigens on leukocytes or leukemia cells in
a single analysis using a microarray of antibodies” (Belov Abstract).
27. Belov’s microarray comprises “antibody dots air-dried on a film of
nitrocellulose bound to a glass microscope slide” (Belov 4484, left-hand
col.).
28. “Leukocytes were isolated from peripheral blood . . . and incubated
with the [ ] Array for 30 min at room temperature . . . and unbound cells
7
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