Appeal 2007-2955
Application 10/190,425
provide high content spatial information at the cellular and subcellular level
as well as temporal information about changes in physiological, biochemical
and molecular activities” of living cells (id. at col. 2, ll. 16-20).
10. “[N]on-uniform micro-patterned cell arrays . . . increase the number
of cell types and specific cell interactions that can be analyzed
simultaneously, . . . in order to provide for high throughput and high
biological content screening of cells” (Taylor, col. 3, ll. 43-49).
11. “[A] non-uniform micro-patterned array of cells . . . can comprise
identical cell types that can be treated with a combinatorial of distinct
compounds, or a combinatorial of cell types that can be treated with one or
more compounds” (id. at col. 6, ll. 49-53).
12. Taylor’s non-uniform micro-patterned cell array is built on a “micro-
patterned chemical array [which] comprises a base [ ] which is treated to
produce a hydrophobic surface across which are dispersed at regular
intervals hydrophilic spots or ‘wells’” (Taylor at col. 8, ll. 33-36).
13. “[T]he term ‘wells’ is used to describe a specific spot on the base, and
does not require any particular depth” (id. at col. 8, ll. 41-42).
14. The wells “may contain a variety of different cell binding molecules
that permit attachment and growth of cells in the wells. The hydrophobic
domains surrounding the wells on the base do not support the attachment
and growth of the cells” (id. at col. 8, ll. 54-57).
15. “[A] non-uniform micro-patterned array of cells refers to an array of
cells on a base . . . [wherein] each ‘well’ or groups of wells on the support
may be unique in its cell binding selectivity” (Taylor, col. 8, ll. 22-27).
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