Ex Parte Brown et al - Page 12

                Appeal 2007-2955                                                                              
                Application 10/190,425                                                                        

                irrelevant.  Wagner and Taylor use the same kinds of capture probes, e.g.,                    
                antibodies, to form their microarrays (FF 17 and 22).  They may differ in the                 
                manner in which the capture probes are attached to their respective                           
                substrates, but we find that one of ordinary skill in the art would have                      
                recognized these different types of attachment as conventional, alternative                   
                ways of immobilizing capture probes in a patterned microarray.                                
                      “Section 103 forbids issuance of a patent when ‘the differences                         
                between the subject matter sought to be patented and the prior art are such                   
                that the subject matter as a whole would have been obvious at the time the                    
                invention was made to a person having ordinary skill in the art to which said                 
                subject matter pertains.’”  KSR at 1734, 82 USPQ2d at 1391.                                   
                      We find that the Examiner has established a prima facie case that the                   
                invention of claim 1 would have been obvious over the prior art, which                        
                Appellants have not overcome by argument or evidence.  As discussed                           
                above, claims 2-4, 6, 10, 31, and 33 fall with claim 1.  Accordingly, the                     
                Examiner’s rejection of claims 1-4, 6, 10, 31, and 33 under 35 U.S.C.                         
                § 103(a) as unpatentable over Belov, Chang, Taylor, and Wagner is                             
                affirmed.                                                                                     











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