Appeal No. 93-4005
Application 07/795,158
2. New ground of rejection under 37 CFR § 1.196(b)
Claims 3, 4 and 6 are rejected under 35 U.S.C. § 103 as
being unpatentable over (1) Tanner, (2) Kirk-Othmer, (3)
German Patent 29 20 592, (4) Babayan, (5) Reyes and (6) the
two Lahoz publications.
Tanner and Kirk-Othmer confirm what applicant readily
concedes, i.e., "[t]he preparation of riboflavin (vitamin B )
2
by microbial fermentation process is known" (specification,
page 1, lines 7-8). One microbial fermentation uses the
microorganism Ashbya gossypii.
German Patent 29 20 592 reveals that it is desirable to
achieve cell lysis (page 4) in making riboflavin a microbial
fermentation using Ashbya gossypii as the microorganism.
Babayan teach that in certain fungi (i.e., those which
are not yeasts), autolysis involving both cytoplasmatic
membrane and cell wall destruction can be achieved through the
use of various physical, chemical and biological factors. The
second Lahoz article confirms to some extent what Babayan is
saying (page 1901, col. 1). The first Lahoz publication tells
us that, in the case of filamentous fungi, autolysis is
- 19 -
Page: Previous 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 Next
Last modified: November 3, 2007