Ex parte RAIKHEL et al. - Page 9




          Appeal No. 94-2156                                                           
          Application 07/888,366                                                       
          the same -Trp-Gly-Trp-Cys- internal sequence (Trp has a unique               
          codon) as the known 43 amino acid sequence of mature hevein                  
          (Ans., pp. 9-11), yet the fact that appellants’ claims are                   
          drawn to cDNA which encodes a novel 204 amino acid precursor                 
          is not considered to be a material distinction.  We disagree.                
               The examiner states (Ans., pp. 11-13, bridging para.                    
          (3)):                                                                        
                    While applicants urge that the actual gene                         
               expression product and encoding cDNA sequence are                       
               larger than the known hevein protein having only                        
               43 amino acids, one of ordinary skill in the art                        
               in carrying out the method of Weissman . . . would                      
               have inherently or inevitably obtained the full-length                  
               cDNA sequence corresponding to the gene encoding the                    
               protein which included these 43 amino acids . . . .                     
          In our view, the examiner erroneously equates the requisite                  
          “likelihood of success” to inevitability.  Rather, for                       
          obviousness under 35 U.S.C. § 103, persons having ordinary                   
          skill in the art would have had to have a reasonable                         
          expectation of success in view of the cited prior art.  See In               
          re O’Farrell,                                                                
          853 F.2d at 904, 7 USPQ2d at 1681 (“For obviousness under §                  
          103, all that is required is a reasonable expectation of                     
          success.”)                                                                   
          The examiner predicts (Ans., p. 12, l. 12-17):                               

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