Ex parte CALLAGHAN et al. - Page 25




          Appeal No. 96-2179                                          Page 25           
          Application 07/613,466                                                        
          F.   Obviousness                                                              
               13. We agree with the examiner that Callaghan '900 and                   
          Nappholz can be combined.  Callaghan '900 would have motivated                
          a person having ordinary skill in the art to a closed-loop                    
          control pacemaker using the depolarization gradient as its                    
          rate control parameter.  Nappholz would have motivated a                      
          person having ordinary skill in the art to find a way to make                 
          the depolarization gradient self-adapting.  It does not                       
          follow, however, that the artisan is more likely than not to                  
          have arrived at the claimed subject matter.  We do not find                   
          sufficient evidence of record to support a conclusion of                      
          obviousness.  Accordingly, we reverse this rejection of                       
          claims 28, 30-33, 35-37, 52-57, and 59-61.                                    
                                       DECISION                                         
               We affirm the rejection of claims 1-24 and 38-48 under                   
          section 112 as indefinite.  The reference-based rejections of                 
          these claims are reversed pro forma.                                          
               We reverse the rejection of claims 25-37 and 49-61 under                 
          section 112 as indefinite on the merits.                                      
               The rejection of claims 1-61 under section 112 as not                    
          enabled is reversed pro forma.                                                









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