Appeal No. 97-1999
Application 07/390,745
21, all claims pending in this application.
1. Introduction
Claims 15-21 stand rejected under 35 U.S.C. § 102(b) as
fully described by Schröder et al. (Schroder), U.S. 4,554,017,
patented November 19, 1985. Claims 1-21 stand rejected under
35 U.S.C. § 103 as being unpatentable in view of the combined
teachings of Nadler et al. (Nadler), “1-Aminocyclopropane-1-
Carboxylic Acid (ACC) Mimics the Effects of Glycine on the
NMDA Receptor Ion Channel,” European Journal of Pharmacology,
Vol. 157, pp. 115-116 (November 1988)(prima facie prior art
under
35 U.S.C. § 102(a)); Marvizón, Lewin, and Skolnick (Marvizon),
“1-Aminocyclopropane Carboxylic Acid: A Potent and Selective
Ligand for the Glycine Modulatory Site of the N-Methyl-D-
Aspartate Receptor Complex,” Journal of Neurochemistry, Vol.
52, No. 3, pp. 992-994 (March 1989)(prima facie prior art
under
35 U.S.C. § 102(a)); Chemical Abstracts (Ross), Vol. 85, No.
4,
AB-743, Abstract No. 39814 (1987); Robinson et al. (Robinson),
“Glutamate and Related Acidic Excitatory Neurotransmitters:
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