Appeal No. 97-1999
Application 07/390,745
A C=O
\ / \
C B Formula I
/ \
C - C
wherein A is -NH , -NHR or -NR R ; B is -OH or -OR ;2 1 1 2 3
R , R and R , same or different, are selected from lower1 2 3
alkyl, which may be substituted by halogen, hydroxyl,
lower alkoxy, oxo, mercapto, aryl or amino; or a
pharmaceutically acceptable salt thereof.
15. A pharmaceutical composition for the treatment
of a neuropsychopharmacological disorder which results
from or is associated with excessive activation of the
N-methyl-D-aspartate receptor complex, comprising:
(a) a compound having the formula:
A C=O
\ / \
C B Formula I
/ \
C - C
wherein A is -NH , -NHR or -NR R ; B is -OH or -OR ;2 1 1 2 3
R , R and R , same or different, are selected from lower1 2 3
alkyl, which may be substituted by halogen, hydroxyl,
alkoxy, oxo, mercapto, aryl or amino; or a
pharmaceutically acceptable salt thereof; and
(b) a pharmaceutically acceptable carrier thereof
suitable for administration to a patient, wherein when
the
carrier is water, the carrier further includes isotonic
agents.
2. Discussion
A. The section 102 rejection
We reverse the examiner’s rejection of Claims 15-21 under
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