Ex parte COVEY et al. - Page 3




          Appeal No. 95-2726                                                          
          Application 07/994,477                                                      
          Hunkapiller et al. (Hunkapiller), “Contemporary Methodology                 
          for Protein Structure Determination,” Science, vol. 226, pp.                
          304-311 (1984).                                                             
          Biemann, “Mass Spectrometric Methods for Protein Sequencing,”               
          Anal. Chem., vol. 58, pp. 1288A-1300A (1986).                               


          Olivares et al. (Olivares), “On-Line Mass Spectrometric                     
          Detection for Capillary Zone Electrophoresis,” Anal. Chem.,                 
          vo1. 59, pp. 1230-1232 (1987).                                              
          Bruins et al. (Bruins), “Ion Spray Interface for Combined                   
          Liquid Chromatography/Atmospheric Pressure Ionization Mass                  
          Spectrometry,”  Anal. Chem., vol. 59, pp. 2642-2646 (1987).                 

               The claims stand rejected under 35 USC § 103 as being                  
          unpatentable over Biemann and Yost in view of Bruins, Henion,               
          Vestal, Olivares and Hunkapillar.                                           
               Having carefully considered the record before us which                 
          includes, inter alia, the specification, the appellants’ main               
          Brief (Paper No. 33), Reply Brief (Paper No. 35), the                       
          examiner’s Answer (Paper No. 34) and the declarations of Drs.               
          Covey, Aebersold and Carr (Paper Nos. 20, 27 and 29,                        
          respectively), we find ourselves in substantial agreement with              
          the appellants’ position.  Accordingly, we reverse the                      
          rejection.                                                                  
               In the case before us, we need not determine whether the               


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