Appeal No. 95-2726 Application 07/994,477 Hunkapiller et al. (Hunkapiller), “Contemporary Methodology for Protein Structure Determination,” Science, vol. 226, pp. 304-311 (1984). Biemann, “Mass Spectrometric Methods for Protein Sequencing,” Anal. Chem., vol. 58, pp. 1288A-1300A (1986). Olivares et al. (Olivares), “On-Line Mass Spectrometric Detection for Capillary Zone Electrophoresis,” Anal. Chem., vo1. 59, pp. 1230-1232 (1987). Bruins et al. (Bruins), “Ion Spray Interface for Combined Liquid Chromatography/Atmospheric Pressure Ionization Mass Spectrometry,” Anal. Chem., vol. 59, pp. 2642-2646 (1987). The claims stand rejected under 35 USC § 103 as being unpatentable over Biemann and Yost in view of Bruins, Henion, Vestal, Olivares and Hunkapillar. Having carefully considered the record before us which includes, inter alia, the specification, the appellants’ main Brief (Paper No. 33), Reply Brief (Paper No. 35), the examiner’s Answer (Paper No. 34) and the declarations of Drs. Covey, Aebersold and Carr (Paper Nos. 20, 27 and 29, respectively), we find ourselves in substantial agreement with the appellants’ position. Accordingly, we reverse the rejection. In the case before us, we need not determine whether the 3Page: Previous 1 2 3 4 5 6 7 NextLast modified: November 3, 2007