Ex parte GHIONE et al. - Page 8


            Appeal No. 1995-3257                                                        
            Application 08/056,382                                                      



                  The crux of the inquiry lies in a comparison of the                   
            claims.  In re Borah, 354 F.2d 1009, 1017, 148 USPQ 213,                    
            220 (CCPA 1966).  When comparing the claims, we see that                    
            patent claim 1 is directed to a specific monoclonal                         
            antibody while claim 19 provides for:                                       
               a topical pharmaceutical composition useful for                          
                  decreasing the toxic affect [sic] in animals caused                   
                  by the administration of an anthracycline antibiotic                  
                  for cytostatic therapy;                                               
               an antidotal effective amount of the antibody of patent                  
                  claim 1; and,                                                         
               a pharmaceutically acceptable topical carrier.                           
            Therefore, in assessing whether claim 19 is patentably                      
            distinct from patent claim 1, it is incumbent on examiner                   
            to demonstrate that the three additional features listed                    
            supra are not indicative of the existence of patentable                     
            differences over patent claim 1.  General Foods Corp. v.                    
            Studiengesellschaft Kohle mbH, 972 F.2d 1272, 1278-79, 23                   
            USPQ2d 1839, 1844 (Fed. Cir. 1992).  In this respect,                       
            examiner (examiner's answer, p. 4) states:                                  
               "Although the conflicting claims are not identical,                      
               they are not patentably distinct from each other                         
               because they vary only in the recitation of various                      
               carriers and in the recitation of an intended use.                       
               Because the prior art and claimed antibody are the                       
               same, it would have been obvious to formulate the                        
               claimed antibodies with at [sic] topical carrier for                     
               any [examiner's emphasis] desired use of said                            
               antibodies, because it is known in the art that                          

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