Ex parte GHIONE et al. - Page 10


            Appeal No. 1995-3257                                                        
            Application 08/056,382                                                      




                  After careful review of examiner's position, we                       
            conclude that examiner has not demonstrated that claim 19                   
            is an obvious variation of patent claim 1.  We reach this                   
            decision for two reasons.                                                   
                  First, an essential element of claim 19 - "an                         
            antidotal effective amount" of the antibody - is ignored.                   
            This feature presents a limitation on the antibody within                   
            the remaining topical composition and places a constraint                   
            not suggested in patent claim 1.  The purpose of                            
            supplying this amount is to decrease the toxic effect in                    
            animals caused by administration of an anthracycline                        
            antibiotic (claim 19, preamble).  Patent claim 1 is                         
            directed broadly to the antibody and recites no                             
            particular amount.  For claim 19 to be an obvious                           
            variation of patent claim 1, examiner would have to show                    
            that it would have been obvious to provide an antidotal                     
            effective amount of the antibody of patent claim 1.                         
            However, no reason for doing so is given.                                   
                  Second, examiner dismisses the "use" language and                     
            carrier recited in claim 19 because they are conventional                   
            but does not explain why they would have been obvious                       


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