Appeal No. 1996-0783 Page 3
Application No. 08/102,297
separation matrix are under a volume compression of
between 14 10 [sic, to] 43 percent; and 2
d) a cover portion having an aperture, the cross-
sectional area of which aperture is less than 90
percent of the said separation matrix.
19. A process of rapidly detecting an analyte in a
biological fluid, said process comprising the steps of:
a) providing a detection device comprising:
i) means for detecting said analyte;
ii) a separation matrix vertically adjacent to,
compressed to and coincident with said detection
means such that said analyte can move from said
separation matrix to said detection means, wherein
said detection means and said separation matrix are
under a volume compression of 14 to 43 percent;
iii) a cover portion having an aperture, the
cross-sectional area of which is less than 90
percent of the cross-sectional area of the said
separation matrix; and
iv) a base portion containing an access means to
allow detection of an analytical signal generated by
the detection means;
b) applying a volume of a sample of said biological
fluid, wherein the volume is as low as five to ten
microliters, to said separation matrix;
c) maintaining said detection device at a
temperature and for a period of time sufficient for said
analyte to traverse said separation matrix, enter said
2An appropriate amendment correcting the noted
typographical error should be made prior to the final
disposition of this application.
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