Appeal No. 1995-2297 Application No. 07/797,493 of mouse origin, and human cells account for only approximately 0.3 to 3.0% of the bone marrow in Kamel. See, Brief, pages 6 and 10. Appellants contrast the prior art with the bone marrow of their mice in which at least 30% of the cells are of human origin. See, Brief, pages 6 and 10. We affirm the examiner with regards to claims 4 and 6-8, and 2 reverse the examiner’s rejection as it applies to claims 1 and 2. “Where a product-by-process claim is rejected over a prior art product that appears to be identical, although produced by a different process, the burden is upon the applicants to come forward with evidence establishing an unobvious difference between the claimed product and the prior art product. In re Best, 562 F.2d [1252,] 1255, 195 USPQ [430,] 433[ (CCPA 1977)].” In re Marosi, 710 F.2d 799, 803, 218 USPQ 289, 292-93 (Fed. Cir. 1983). Appellants demonstrate that the bone marrow is comprised of at least 30% human origin. However, as the examiner notes, this distinction over the prior art is not 2We recognize appellant’s request that claims 1, 2, 4 and 6-8 stand or fall together, however, upon review of this record, we have determined that claims 1 and 2 can be properly distinguished from claims 4 and 6-8. Therefore, we have considered claims 1 and 2 separate from claims 4 and 6-8. 11Page: Previous 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 NextLast modified: November 3, 2007