Appeal 1995-2560
Application 07/833,973
solubility. For example, Zaffaroni preliminarily states, “The
compounds of the invention preferably are water soluble and in
use pass through the length of the gastrointestinal tract
without degradation and without being absorbed from said
gastrointestinal tract into the body of the host” (col. 1, l.
27-31; emphasis added). Later, Zaffaroni teaches:
The compounds of the invention bearing a basic
group, such as amino or the like, can be converted to
non-toxic acid addition salts having improved aqueous
solubility to enhance their use in foods, beverages
and medicines.
(col. 18, l. 4-8);
The nonnutritive flavor imparting compounds and
intermediates used to prepare same when bearing
at least one carboxyl functionality can also be used
in the form of their base addition salts that have
improved solubilities in aqueous media and other
carrier systems.
(col. 18, l. 26-30);
The solubilities of the nonnutritive flavor
imparting compounds, or of intermediates leading
thereto, also can be regulated by acylating the free
hydroxyl group of the compound or the polymer or both.
(col. 18, l. 58-62); and
The hydroxyl group attached to a nonnutritive
flavor imparting compound, a polymer or an intermediate
can optionally be etherified to form ether derivatives
that have desirable solubilities in various media,
carriers, foods, beverages and medicines.
(col. 19, l. 34-38).
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