Appeal No. 1996-0111
Application 08/041,428
levels in the animal. Of particular relevance is that portion of Tamura I at page 992, column
2, first full paragraph which states:
the serum levels of . . . mucoproteins in cattle with hepatic abscess were
much higher than those of healthy controls, and pointed out that the
measurements of these serum markers were useful for determination of the
prognosis of cattle with inflammatory diseases and also for monitoring the
effectiveness of therapy.
Tamura I also suggests at page 993, column 1, second full paragraph that the evaluation of
serum " -AG levels may provide a useful markers for the screening for various
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abnormality. Similarly, Tamura II in the last paragraph of the translation would reasonably
appear to describe the determination of the level of " -AGP in normal healthy cattle's milk,
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compares this with the level of " -AGP in cattle with mastitis, monitors the decrease to
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normal levels of this elevated level of " -AGP after treatment with antibiotics, notes that the
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elevated levels reappeared upon reappearance of mastitis and concludes that "it is
significant to measure AGP . . . in milk in order to track or observe the mastitis treatment."
Itoh also states (page 1296, column 1, last paragraph):
Those results suggest that serum " -AG level in recovered cases was not
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increased, while it was high in unrecovered cases. As an indicators for the
diagnosis of inflammatory disease, the assay of serum " -AG seemed to be
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very useful for evaluation of an appropriate treatment and of condition of
postoperative course in cattle.
Thus, these references reasonably appear to describe a process for monitoring or
managing a group of animals, including cattle, where the normal levels of " -AGP of
1
healthy animals is determined, the AGP levels are monitored in diseased animals, and this
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