Ex parte FRASCOTTI et al. - Page 4




          Appeal No. 1996-1042                                                        
          Application No. 07/810,138                                                  


                                     DISCUSSION                                       
               Initially, we note that the recitation "spoII:D" in                    
          claims 9 and 14 appears to be incorrect.  We believe that                   
          appellants intend "spoII:D ," consistent with the description-                                                 
          in the specification, page 5, line 9 and with the recitation                
          of an asporogenous strain of Bacillus subtilis.  On return of               
          this application to the Examining Group, we recommend that                  
          both appellants and the examiner clarify this matter.                       
               Claims 9 through 13 stand rejected under 35 U.S.C. § 112,              
          first paragraph, as based on a non-enabling disclosure.                     
          According to the examiner, the specification does not teach                 
          how to make the claimed biologically pure culture of                        
          asporogenous strain Bacillus subtilis SMS275, suitable for use              
          as a host component in a host-vector system.  We disagree.                  
               As set forth in the specification, page 4, fourth                      
          paragraph:                                                                  
               An asporogenous mutant of B.subtilis which overcomes                   
               the problems described above has now been isolated.                    
               This mutant, known as SMS275, has been deposited on                    
               October 5, 1990 at the Centraalbureau Voor                             
               Schimmelcultures where it received the number CBS                      
               432.90.                                                                



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