Appeal No. 1996-3017
Application No. 08/851,810
2. A process for preparation of alkyl-pyrazine compounds
comprising heating and refluxing an aqueous medium containing
ammonium ions and at least one acyloin compound having the
general formula:
H
*
R - C - C - R 1 2
* 5
OH O
wherein R and R are methyl groups, to obtain a reacted1 2
mixture, adding a base to the reacted mixture to adjust the pH
of liquid of the reacted mixture to an alkaline pH, separating
reacted mixture solid material from the pH-adjusted liquid,
adding water to the separated solid material to dissolve the
solid material to form a solution, allowing a product to
crystallyze [sic] from the solution, thereby forming a solid
crystalline product and a liquid phase, and then separating
the crystalline product from the liquid phase.
The examiner relies upon the following references as
evidence of obviousness:
Langdon 3,067,199 Dec. 4, 1962
Bonzom et al. (Bonzom) 3,676,442 Jul. 11, 1972
Kosuge et al. (Kosuge) Sho 52-97983 Aug. 17, 1977
(Japanese Kokai patent application)
4 Technique of Organic Chemistry 613-28, 627-28 (Arnold
Weissberger, ed., Interscience Publishers, Inc., New York
1951)
R.F. Evans et al. (Evans), "Diazabenzenes. I. Synthesis of
Some t-Butylpyrazines and Their N-Oxides," 25 Australian
Journal of Chemistry 2671-85 (1972)
-2-
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