Ex parte MARCHIONNI et al. - Page 3




              Appeal No. 1996-3330                                                                                          
              Application 07/861,458                                                                                        



                     (e) using additional two or more probes based on two or more conserved regions                         
              among said structural homologues and said gene to detect hybridization signals in the                         
              genome of an additional organism which is positioned phylogenetically between said first                      
              organisms and said additional organism; and                                                                   
                     (f) repeating steps b through e until said structural homologue of said first organism                 
              is identified.                                                                                                

                     The references relied upon by the examiner are:                                                        
              Webster                              5,087,558                           Feb. 11, 1992                        
              Chalfie et al. (Chalfie), "The Identification and Suppression of Inherited Neurodegeneration                  
              in Caenorhabditis elegans," Nature, Vol. 345, pp. 410-416 (1990)                                              

              Goddard et al. (Goddard), "Isolation and Characterization of Caenorhabditis elegans                           
              DNA Sequences Homologous to the v-abl Oncogene," Proc. Natl. Acad. Sci. USA, Vol 83,                          
              pp. 2172-2176 (1986)                                                                                          
              Libert et al. (Libert), "Selective Amplification and Cloning of Four New Members of the G                     
              Protein-Coupled Receptor Family," Science, Vol. 244, pp. 569-572 (1989)                                       

                                                  Grounds of Rejection                                                      

                    Claims 38-54, 58-60, 66-81, and 85-87 stand rejected under 35 U.S.C. § 112, second                      
             paragraph, as failing to particularly point out and distinctly claim the invention.                            
                    Claims 38-54, 58-60, 66-81, and 85-87 stand rejected under 35 U.S.C. § 103.  As                         
             evidence of obviousness, the examiner relies upon Chalfie, Goddard, Webster, and Libert.                       
                    We reverse.                                                                                             
                                                      Background                                                            

                     The applicants describe the invention, at page 2 of the specification, as being                        
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