Ex parte MARCHIONNI et al. - Page 9




              Appeal No. 1996-3330                                                                                          
              Application 07/861,458                                                                                        


              suggestion, or motivation found in the prior art whereby a person of ordinary skill in the field              
              of the invention would make the substitutions required.  That knowledge can not come                          
              from the applicants' invention itself.  Diversitech Corp. v. Century Steps, Inc.,  850 F.2d                   
              675, 678-79,  7 USPQ2d 1315, 1318 (Fed. Cir. 1988); In re Geiger, 815  F.2d 686, 688, 2                       
              USPQ2d 1276, 1278 (Fed. Cir. 1987);  Interconnect Planning Corp. v. Feil, 774 F.2d                            
              1132, 1143,  227 USPQ 543, 551 (Fed. Cir. 1985).  The extent to which such suggestion                         
              must be explicit in or may be fairly inferred from, the references, is decided on the facts of                
              each case, in light of the prior art and its relationship to the invention.  It is impermissible,             
              however, simply to engage in a hindsight reconstruction of the claimed invention using                        
              applicants' disclosed invention as a template and selecting elements from references to fill                  
              the gaps.  In re Gorman, 933 F.2d 983, 986-987, 18 USPQ2d 1885, 1888 (Fed. Cir.                               
              1991).  Here, the examiner has provided no facts or evidence which would have                                 
              reasonably led one of ordinary skill in this art to the method of isolating unknown structural                
              homologues of genes identified in a phylogenetically related animal in the manner claimed.                    
              Where, as here, the examiner fails to establish a prima facie case of obviousness, the                        
              rejection is improper and will be overturned.  In re Fine, 837 F.2d 1071, 1074, 5 USPQ2d                      
              1596, 1598 (Fed. Cir.1988).  The rejection of claims 38-54, 58-60, 66-81, and 85-87                           
              under 35 U.S.C. § 103 is reversed.                                                                            
                                                       Other Issues                                                         


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