Appeal No. 1996-3434
Application No. 08/063,279
mixture of equimolar amounts of linear oligoalkyleneimine chain members containing
the same number of about two to about ten alkyleneimine repeating units in each chain,
each of said alkyleneimine repeating units having a length of two to about six carbon
atoms and having a reduced amino acid side chain bonded to the carbon atom alpha
to the nitrogen atom in which the carboxamide groups of said reduced amino acid side
chains are replaced by aminomethyl groups, carboxyl groups of said reduced amino
acid side chains are replaced by hydroxymethyl groups, and guanidino groups of said
reduced amino acid side chains are replaced by amino groups, the members of said
library having one or more of said repeating units containing a predetermined reduced
amino acid side chain at the same one or more predetermined positions of the
oligoalkyleneimine chain, and the library having equimolar amounts of repeating units
that contain at least six different of said reduced amino acid side chains at one or more
of these same other positions of the oligoalkyleneimine chain, a first terminus of each of
said oligoalkyleneimines in the library having a hydrogen, benzyl or C1-C18 hydrocarbyl
group bonded to an amino group, and the second terminus being a hydroxyl or
methylamino group.
The references relied upon by the examiner are:
Nyéki et al. (Nyéki) 5,093,320 Mar. 3, 1992
Lam et al. (Lam) WO 92/00091 Jan. 1, 1992
Raucher et al. (Raucher), AA Convenient Method For The Selective Reduction of
Amides to Amines@ Tetrahedron Letters, Volume 21, pp. 4061-64 (1980)
Houghten et al. (Houghten), AGeneration and use of synthetic peptide combinatorial
libraries for basic research and drug discovery@ Nature, Volume 354, pp. 84-86 (1991)
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