Appeal No. 1996-3434
Application No. 08/063,279
THE REJECTIONS UNDER 35 U.S.C. ' 103:
At page 4 of the Answer the examiner explains what each reference is relied
upon to teach. The examiner states:
Houghten et al. teach the generation and use of
synthetic peptide combinatorial libraries (SPCLs). The
peptides consisted of six residue peptide sequences with
acetylated N terminal and amidated C terminals. The first
two positions of these libraries were individually and
specifically defined . . . This reference fails to teach
reduction of the peptides to produce oligoalkyleneimines,
such as oligoethyleneimines.
Lam et al. teach the production of random bio-
oligomer libraries, in which the monomer unit may be an
amino acid, an amino acid analog, or a peptidomimetic . . .
This reference also teaches that a peptide library may be
generated that incorporates a reduced peptide bond, i.e.
R1-CH2-NH-R2.
Raucher et al. teach a convenient, general, and
selective method for the rejection of amides to amines.
Appellants= representative confirmed that both the Houghten and Lam
references are available as prior art, during the June 8, 2000 oral hearing for this
appeal.
On page 4 of the Brief, appellants state, A[t]he relied-on art at best teaches a
library whose member chains contain reduced amide bonds, but whose carboxylic acid
or ester functionalities and guanidino functionalities of arginines are intact. Such
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